WNT3A and irritable bowel syndrome: Based on the evidence acquired in our laboratory and previously reported [37], the inflammation induced by DSS for 8 h resembles the gastrointestinal alterations observed in IBS patients, such as (i) low-grade gut inflammation; (ii) goblet cell dysplasia; and (iii) upregulated transcription of both claudin1, as is typically observed in IBS-C patients [38,39], and wnt3a, as is commonly observed during gut inflammation [40].