Furthermore, it is important to consider that CYP27B1 -1260 TT was associated with increased colorectal cancer risk; the CYP27B1 gene encodes a member of the CYP monooxygenases family (the 1α-hydroxylase enzyme), localized to the inner mitochondrial membrane of renal cells [41]. Here, CYP27B1 is linked to colorectal cancer.