Another study by Fang and co-workers indicated that the levels of mitophagy-associated proteins Bcl2L13, PINK1, and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L/NIX) were reduced and mitophagy initiation proteins such as phospho-ULK1 (Ser555) and phospho-TBK1 (Ser172) were inactivated in AD patient samples [100]. This evidence concerns the gene BNIP3L and Alzheimer disease.