Based on model breast cancer and malignant glioma cell lines, it has been proven that statins reducing the invasiveness of pathological cells act through changes in the level of protein phosphorylation and the activation of protein kinases in Rho/Rho kinase (ROCK) and Rho/Focal adhesion kinase (FAK)/Protein kinase B (Akt) pathways. This evidence concerns the gene RHO and malignant glioma.