A recent meta-analysis that included nine studies sought to assess whether non-surgical periodontal therapy could improve rheumatoid arthritis activity and concluded that RA activity was improved as assessed by disease activity score (DAS28), tender joint counts (TJC), swollen joint counts (SJC), visual analogical scale (VAS), and C-reactive protein (CRP) by non-surgical periodontal therapy [6]. This evidence concerns the gene CRP and rheumatoid arthritis.