CXCL10 and Down syndrome: In a previous study, there was a significant increase in CXCL-10 in CSF samples in patients with central nervous system (CNS) inflammatory disorders (acute disseminated encephalomyelitis (ADEM), ADEM followed by optic neuritis, anti-N-methyl-D-aspartate receptor encephalitis, Rasmussen encephalitis, acute cerebellitis of unknown etiology, encephalitis of unknown etiology, clinically isolated syndrome, neuromyelitis optica spectrum disorders, and neuroborreliosis) [8].