In summary, the findings from this figure show: (1) Vegfa and both HIF-1α- and HIF-2α-specific target genes are increased with DMOG treatment, and (2) the infection status of the macrophages does not influence HIF-α activation in response to DMOG, suggesting that the parasite does not directly play a role in macrophage HIF-α activation and, when HIF-α is activated, the parasite does not modulate that response. The gene discussed is VEGFA; the disease is infection.