In addition, TOSO, named Fas inhibitory molecule 3 (FAIM3), is an IgM Fc receptor (FcμR) that is over-expressed in CLL clonal cells; the role of TOSO is not completely clear yet, but it might interact with SYK, enhancing BCR pathways and promoting apoptosis arrest [74]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.