Among the many nanocarriers that have been proposed for improved brain delivery (e.g., polymeric nanoparticles, liposomes, micelles, dendrimers [201]), SLNs have been the most frequently studied and represent a promising strategy for the use of Nrf2 activators for the prevention and treatment of neurodegenerative diseases. The gene discussed is NFE2L2; the disease is neurodegenerative disease.