The molecular mechanism involved in the anticancer potential of curcumin NE in lung adenocarcinoma was found to be a modulation of extracellular receptor kinase, cyclooxygenase-2, protein kinase C, matrix metalloproteinases, and activating transcription factor 2 (ERK 1/2, COX-2, PKC, MMPs, and ATF-2, respectively) signaling pathways [74,75]. This evidence concerns the gene PTGS2 and lung adenocarcinoma.