Mecasermin and mecasermin rinfabate (cluster C4, ATC codes H01AC03, H01AC05) are recombinant insulin-like growth factor-1 drugs indicated in growth failure in children with primary IGF-1 deficiency and, hence, are included in the H–Systemic hormonal preparations, excluding sex hormones and insulins. This evidence concerns the gene IGF1 and hyperinsulinemic hypoglycemia, familial, 4.