For example, several small-molecule inhibitors of the YAP1 transcriptional complex, including Verteporfin, CA3 and vestigial-like protein 4 (VGLL4) mimicking peptide, were shown to have potent antitumor activity in various cancer types, especially inhibiting tumorigenesis, CSCs enrichment and resistance to radiation [117,118,119]. This evidence concerns the gene YAP1 and cancer.