Some of these apoptotic pathways are associated with a decrease in the expression of the antiapoptotic protein Bcl-2 and an increase in the expression of pro-apoptotic caspase-3, Bax, P53, and cytochrome C proteins, as was shown on porcine intestinal IPEC-J2 cells and bladder cancer T24 cells [18,19]. The gene discussed is PROS1; the disease is urinary bladder cancer.