In particular, 10 targets were regulated by MS risk variants at some level in the brain, and among them we observed increased expression levels for seven targets (ASF1A, CAPN1, CARM1, CHAC1, NUP85, POM121C and TRMT112) and decreased levels for three targets (BBC3, MAPK1 and PSMB9). The gene discussed is POM121C; the disease is myeloid sarcoma.