In recent years, many studies have shown that VEGF can also induce the proliferation and differentiation of regulatory cells and myeloid-derived suppressor cells, inhibit the maturation of dendritic cells (DCs), and induce the expression of immunosuppressive molecules PD-L1 in DCs, thereby inhibiting the body’s immune response to tumor cells [10,11,12,13,14]. The gene discussed is CD274; the disease is neoplasm.