Further, dermatopathia pigmentosa reticularis (DPR) and Naegeli-Franceschetti-Jadassohn syndrome (NFJS) are two related dominantly inherited conditions featuring reticulate or mottled hyperpigmentation of the skin that are caused by frameshift mutations, which are located in the head domain of KRT14 [81]. Here, KRT14 is linked to dermatopathia pigmentosa reticularis.