KRT14 and Naegeli-Franceschetti-Jadassohn syndrome: Further, dermatopathia pigmentosa reticularis (DPR) and Naegeli-Franceschetti-Jadassohn syndrome (NFJS) are two related dominantly inherited conditions featuring reticulate or mottled hyperpigmentation of the skin that are caused by frameshift mutations, which are located in the head domain of KRT14 [81].