Based on this, the most striking result of our study was that a better balance between pro- and anti-inflammatory effects as the best anti-tumor effect by TMNPs + HT treatment in 4T1 tumor-bearing mouse model was obtained through the alternation of cytokine levels by MMP inhibition and CXCL-10 promotion, and no tumor progression induced by autocrine CXCL9, -10, -11/CXCR3 signaling in TMNPs or TMNPs + HT groups was observed (Figure 6). The gene discussed is CXCR3; the disease is neoplasm.