However, the autocrine CXCL9, -10, -11/CXCR3 signaling axis in cancer cells has the potential to increase proliferation, angiogenesis, and metastasis of cancer cells [96], which indicates the balance between pro-inflammation and anti-inflammation in the tumor microenvironment should be considered during chemoimmunotherapy. The gene discussed is CXCR3; the disease is neoplasm.