Phosphorylation of IκB molecules by inhibitory κB kinase (IKK), in response to cellular stimuli, results in the ubiquitination and proteasomal degradation of IκB, allowing NFκB to enter the nucleus and regulate the target gene expressions associated with cell cycle regulation, proliferation, apoptosis, inflammation, and cancer metastasis [53]. Here, NFKB1 is linked to cancer.