TKS5 and TKS4 are both required for invadopodia formation and the invasive property for multiple human cancer cell lines, with TKS5 playing an early role in the assembly of invadopodia and TKS4 leading to the activation ECM degradation in mature invadopodia (Buschman et al., 2009; Courtneidge et al., 2005; Murphy and Courtneidge, 2011; Saykali and El-Sibai, 2014; Seals et al., 2005). The gene discussed is SH3PXD2B; the disease is cancer.