ATP7B and Wilson disease: LmATP7 is also comprised of a hydrolase region containing TGDN and GXGXND conserved motifs in the ATP-binding site of the nucleotide-binding domain and the SXHP motif whose mutation in human ortholog ATP7B (His1069Gln) is the most frequent contributor to Wilson's disease in the Caucasian population (Fig. 1D).