AKT1 and small cell lung carcinoma: The importance of the mTOR pathway, particularly mTORC2, in the progression and metastasis formation has also been highlighted in our immunohistochemical analysis, in which high expression of both Rictor (the scaffold protein of mTORC2) and phospho-(Ser473)-Akt (the downstream target of mTORC2) has been associated with unfavorable clinical outcome in SCLC patients.