PIK3CA and small cell lung carcinoma: Comprehensive bioinformatic analyses have shown that adherent and semiadherent, chemoresistant SCLC cells are enriched with alterations affecting the PI3K/Akt/mTOR pathway; furthermore, activated PI3K/Akt/mTOR pathway has promoted the phenotypic transition from suspension to adhesion growth pattern as well as the development of chemoresistance.