We also investigated if the rs429358–HCC association varied according to polymorphisms in LDLR because interaction between loci in these genes has been observed for AD and CVD(30, 31, 32) and because APOE is a ligand for the LDLR.(33) Our results from this analysis suggest that the rs429358–HCC association may be stronger for carriers of the rs73015034:C allele in LDLR. Here, APOE is linked to hepatocellular carcinoma.