Both higher levels of IFN-γ expression and higher percentages of IFN-γ+CD8+ T cells and IFN-γ+FoxP3−CD4+ T cells in tumor tissue were observed in the combination of anti-PD-L1 antibody with anti-VEGF antibody group; this was similar to the expression levels of CXCR3 ligands and the percentages of CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.