This suggested that IFN-γ in tumor tissues induced the expression levels of CXCR3 ligands, resulting in CD8+ T cell infiltration in the HM-1 model; however, the mechanism by which only the combination treatment was able to induce the higher levels of IFN-γ and CXCR3 ligands in this model requires further investigation. The gene discussed is CXCR3; the disease is neoplasm.