A transient increase with anti-PD-L1 alone and a maintained increase with the anti-PD-L1 combined with anti-VEGF were also observed in the expression levels of CXCR3 ligands and IFN-γ, and in the percentages of IFN-γ+CD8+ T cells and IFN-γ+FoxP3−CD4+ T cells in tumor tissues. The gene discussed is CD274; the disease is neoplasm.