In present study, we focused on the common SNPs within or near the coding regions of 13 known AD susceptible genes (APOE, A2M, ABCA7, BACE1, BIN1, CLU, CR1, MS4A6A, MS4A6E, NME8, PICALM, PLAU, and SORL1). Here, CR1 is linked to Alzheimer disease.