In present study, we focused on the common SNPs within or near the coding regions of 13 known AD susceptible genes (APOE, A2M, ABCA7, BACE1, BIN1, CLU, CR1, MS4A6A, MS4A6E, NME8, PICALM, PLAU, and SORL1). This evidence concerns the gene APOE and Alzheimer disease.