Most interestingly, neutrophils co‐expressing FasL and PD‐L2 proteins can be induced in vitro simply by using tumor culture supernatants, and these FasL+PD‐L2+ neutrophils exhibit a unique phenotype in vivo, indicating that FasL+PD‐L2+ neutrophil subset can be generated under pathological tumor conditions and that their main role is likely direct immunosuppression. The gene discussed is FASLG; the disease is neoplasm.