In human GC tumors, we now are the first to report the induced high co‐expression of FasL and PD‐L2 on infiltrating neutrophils, which further exhibit suppressive role on activated CD8+ T‐cell proliferation and IFN‐γ production, emphasizing the importance of FasL‐Fas and PD‐L2‐PD‐1 pathways in tumor‐related immunosuppression. The gene discussed is FAS; the disease is gastric cancer.