Moreover, we demonstrate mechanistically that T helper (Th) 17 cell‐derived interleukin (IL)‐17A and tumor cell‐derived granulocyte‐colony stimulating factor (G‐CSF) significantly induce neutrophil FasL and PD‐L2 expression via activating extracellular signal‐regulated kinase (ERK)‐nuclear factor κB (NF‐κB) and Janus kinase (JAK)‐signal transducer and activator of transcription 3 (STAT3) signaling pathway respectively. This evidence concerns the gene STAT3 and neoplasm.