First, the mammalian target of rapamycin complex 1 (mTORC1) is phosphorylated by Akt, which subsequently leads to downstream activation of ribosomal protein S6 kinase 1 and inhibition of eIF4E‐binding protein 1 leading to protein synthesis and in turn cardiac hypertrophy.23, 29, 39. This evidence concerns the gene AKT1 and cardiac hypertrophy.