NOTCH1 and neoplasm: Through designing Synthetic Exosome-Like Nanoparticles (SELN) based on the lipid composition of SOJ-6 exosomes enriched in cholesterol and SM and depleted in phospholipids, they proved the role of lipids (i) in the interaction of SELNs and tumor cells and (ii) in induced cell death with inhibition of the Notch-1 pathway [96].