Kitazawa and others deleted SDHB in HCT116 cells (of colorectal cancer origin) by CRISPR to make an effective drug-screening survey [72].2.1.2Saccharomyces cerevisiae, or yeast, has contributed significantly to understanding the molecular pathogenesis of tumorigenesis resulting from defective SDH [77]. Here, SDHB is linked to colorectal cancer.