We used a publicly available computational model of C-LTMR sensory neurons17 to model C-LTMR excitability, while altering the Nav1.7 conductance (Nav1.7 g-CLTMR, mS/cm2) in accordance with the conductance decrease observed in each CIP participant mutation (Supplementary Table 2). This evidence concerns the gene SCN9A and hereditary sensory and autonomic neuropathy.