To address this question, we took advantage of the recent Nav1.7 mutation characterization from three CIP participants in our cohort.26 From the data available in McDermott et al.26 we were able to calculate the fold decrease in Nav1.7 conductance as a consequence of each SCN9A mutation (Supplementary Table 2). This evidence concerns the gene SCN9A and hereditary sensory and autonomic neuropathy.