CXCL9 and infection: In the high-dose SARS-CoV-2 model, MDR504 substantially suppressed viral load as measured by total and subgenomic N gene expression (Figures 5A and 5B), dramatically reduced number of the infection cells in the lung, evidenced by SARS-CoV-2 viral staining, a method directly evaluating the severity of the lung infection (Figures 5C and 5D) (Han et al., 2020), and inhibited Cxcl9 gene expression (Figure 5E), although this was not significant compared to WT hACE2-Fc.