The percentages of high-risk patients in the death group were significantly higher than those in the survival group for NT-proBNP (FDR <0.001), hs-TNT (FDR <0.001), hs-CRP (FDR = 0.007), GDF-15 (FDR <0.001), MCP-1 (FDR = 0.042), sTNFRI (FDR = 0.013), sTNFRII (FDR = 0.013), endoglin (FDR = 0.013), TIMP-1 (FDR <0.001), TIMP-2 (FDR <0.027), MMP-2 (FDR = 0.006), MMP-9 (FDR = 0.013), galectin-3 (FDR = 0.004), sST2 (FDR = 0.032) and Ascend-HF score (FDR <0.001) (Table 2). The gene discussed is TIMP1; the disease is hydrops fetalis.