As shown in Table 1, log-transformed SERPINA3 levels was independently correlated to the higher risk of CAD, when unadjusted (OR = 1.95, 95% CI: 1.27–2.98, P = 0.002), adjusted for Model1 (OR = 2.15, 95% CI: 1.29–3.57, P = 0.003) and adjusted for Model 2 (OR = 2.44, 95% CI: 1.33–4.51, P = 0.004). This evidence concerns the gene SERPINA3 and coronary artery disorder.