IKKβ has been shown to be a key adipocyte survival factor in obesity, and deficiency of IKKβ in adipocytes can lead to high fat feeding-elicited cell death, impaired adipose tissue remodeling and partial lipodystrophy in visceral adipose tissue (59, 60). The gene discussed is IKBKB; the disease is obesity due to melanocortin 4 receptor deficiency.