When compared with the control group, several genes related to atherosclerosis were differentially expressed in the case group (Up: Apob in fibroblasts; Cyp7a1 in VSMCs; Down: Pcsk9, Apoa2, Crp, Cyp7a1 in fibroblasts; Apoa1 in macrophages; Alb in transitional cells, Figure 6C). This evidence concerns the gene PCSK9 and atherosclerosis.