Other relatively commonly encountered amyloidogenic mutations include those encoding the p.V50M and p.T80A TTR variants, which typically present at a younger age than wtATTR-CM with a combination of neuropathy and cardiomyopathy, or in the case of early-onset p.V50M with neuropathy in the absence of cardiomyopathy. This evidence concerns the gene TTR and cardiomyopathy.