There are over 130 pathogenic mutations of the TTR gene and although there is considerable overlap, there is a reasonably strong association between the specific mutation and the predominant clinical phenotype with certain mutations giving rise to predominant ATTR-CM, others predominant ATTR-PN, and the majority associated with a mixture of neuropathy and cardiomyopathy (23). The gene discussed is TTR; the disease is cardiomyopathy.