Moreover, recommended HF-associated biomarkers, including B-type natriuretic peptide (BNP) and N-terminal probrain natriuretic peptide (NT-proBNP), lack specificity that they can also exhibit elevated levels in patients with congestive HF, renal failure, primary aldosteronism, and thyroid disease (14–16). This evidence concerns the gene NPPB and hydrops fetalis.