Moreover, recommended HF-associated biomarkers, including B-type natriuretic peptide (BNP) and N-terminal probrain natriuretic peptide (NT-proBNP), lack specificity that they can also exhibit elevated levels in patients with congestive HF, renal failure, primary aldosteronism, and thyroid disease (14–16). The gene discussed is NPPB; the disease is Renal insufficiency.