For example, the GR is one of the most widely studied Hsp90 clients, and changes in activity of GR and/or other clients due to altered abundance of associated cochaperones has been linked to mood disorders, autism, anxiety, psychotic illness, depression, and altered pain susceptibility (Sinclair et al., 2013; Patel et al., 2016; Baker et al., 2018; Lee et al., 2019; Lou et al., 2021; Mokha et al., 2021; Salhi et al., 2021; Szczepankiewicz et al., 2021). This evidence concerns the gene NR3C1 and major depressive disorder.