EGFR and lung carcinoma: For instance, some lung cancer cell lines, such as H3255(EGFR L858R) and PC9(EGFR del19), demonstrated sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) Osimertinib, rociletinib, erlotinib, and afatinib, whereas HCC827(EGFR del19) is sensitive to gefitinib or erlotinib or the EGFR inhibitory antibody cetuximab.