TMPRSS2 and infection: Dugail et al. (2020) (9) and others (8, 10) have postulated that the infection of the adipose tissue by SARS-CoV-2 via angiotensin-converting enzyme 2 (ACE2) receptor expression and transmembrane protease serine 2 (TMPRSS2) might be involved with virus replication in WAT, increased lipolysis (releasing fatty acids into the circulation, including the inflammation-inducing saturated fatty acids), production and secretion of lipid active metabolites, cytokines, and dysregulation of WAT endocrine function.