When hemoglobin is <5 g/dL, early use of HBOC-201 can improve the patient's chance of survival. HBOC-201 transfusion avoidance of 96% for 24 h, 70% for 1 week. More non-serious events occurred in the HBOC-201 group. Age, history of heart disease, and Hb deficiency are predictors of cardiac ischemic events. Here, GSTM1 is linked to heart disorder.