In addition, an increase in activation of CD4+ T lymphocytes was documented both in peripheral blood and liver (based on the expression of HLA-DR) (226); Th17 was found to be more abundant in the liver of patients with NASH than in those with NAFL and in circulating blood of NASH patients Th17/Treg ratio was found to be higher than that of NAFL ones. The gene discussed is CD4; the disease is non-alcoholic fatty liver.