APOE and early-onset autosomal dominant Alzheimer disease: Regarding the rising related topics, “Vascular Dementia,” “Older People,” “Apolipoprotein E,” and “Acetyl Choline,” exhibited an increase over 5,000%, followed by “Alzheimer's Disease and Related Disorders Association”(n = 350), “Early onset Alzheimer's disease”(n = 300), “Cognitive” (n = 200), “Dementia” (n = 160), “Parkinson's disease” (n = 110), “Caregiver”(n = 100), and “Agedness”(n = 80).