PTPN9 harbors a lipid-binding Sec14 domain that target the enzyme to secretory vesicles, regulating vesicle size and fusion, and PTPN9 has been shown to directly dephosphorylate TrkA in P19 neuroblastoma cells, which would regulate its transport to the plasma membrane (Zhang et al., 2016). Here, PTPN9 is linked to neuroblastoma.