In addition, PTPN11 is mutated in the germline of patients with several developmental disorders (Noonan Syndrome [NS], and NS-related syndromes) and hematological malignancies (Juvenile Myelomonocytic Leukemia [JMML], and other childhood leukemias) (Huang et al., 2014; Tajan et al., 2015). Here, PTPN11 is linked to juvenile myelomonocytic leukemia.