PTPN11 is among the genes more frequently mutated in neuroblastoma, especially in relapsed tumors, with a mutation distribution pattern similar to the one found in other human cancers (Gröbner et al., 2018; Ma et al., 2018; Pugh et al., 2013; Eleveld et al., 2015) (https://cancer.sanger.ac.uk; https://pecan.stjude.cloud). The gene discussed is PTPN11; the disease is cancer.