PTPN1 (PTP1B), the founding member of the PTP gene family (Tonks, 2013), is an ubiquitously expressed negative regulator of insulin signaling, and it plays both oncogenic and tumor suppressor roles in human cancer (Bakke and Haj, 2015; Feldhammer et al., 2013). This evidence concerns the gene PTPN1 and neoplasm.