Knock-down of PTPN1 in SH-SY5Y cells increased the protein phospho-tyrosine content upon EGF stimulation, as well as cell proliferation, whereas high PTPN1 protein expression in neuroblastoma tumors associated with poor prognosis (Nunes-Xavier et al., 2019b). The gene discussed is PTPN1; the disease is neuroblastoma.