PTPN1 and anaplastic large cell lymphoma: In addition, PTPN1 and PTPN2 have been shown to dephosphorylate ALK and PTPN11 in anaplastic large cell lymphomas, and gene deletion of either PTPN1 or PTPN2 induced resistance to ALK inhibitors (Karaca Atabay et al., 2021).