In this regard, PTPRZ1 protein is abundantly expressed in neuroblastoma tumors, and PTPRZ1 mRNA expression is induced in neuroblastoma cell lines upon cell differentiation, although its expression in adrenal gland or in neuroblastoma cells under normal cell growth conditions seems to be very low, making difficult a quantitative comparison (Nunes-Xavier et al., 2019b). Here, PTPRZ1 is linked to neuroblastoma.