In this regard, expression of TrkA and TrkC in the absence of their ligands triggers neuronal apoptosis, which has been associated with spontaneous neuroblastoma regression (Bouzas-Rodriguez et al., 2010; Nikoletopoulou et al., 2010; Brodeur, 2018), although it should be mentioned that the expression of the alternative TrkA splice variant TrkAIII associates with advanced neuroblastoma, and TrkAIII displays oncogenic properties in neuroblastoma cell models (Farina et al., 2018). The gene discussed is NTRK1; the disease is neuroblastoma.