Other relevant tyrosine-phosphorylated effectors in the propagation of the oncogenic cell signaling in neuroblastoma cells, which also constitute potential therapeutic targets and PTP direct substrates, include Src-family kinases (SFK) (Bieerkehazhi et al., 2017; Molinari et al., 2018), JAK and STAT kinases (Yan et al., 2013; Yogev et al., 2019), Bruton tyrosine kinase (BTK) (Li et al., 2018; Pikatan et al., 2020), and MYCN stabilizing Aurora-A kinase (AURKA) (Brockmann et al., 2013; Roeschert et al., 2021), among others (Figure 1). Here, BTK is linked to neuroblastoma.