Interestingly, PAQR3 a Golgi scaffolding protein (also named RKTG for Raf kinase trapping to the Golgi) is actively involved in the degradation of Twist1, a critical transcription factor required for the initiation of EMT and metastasis of tumor cells (Guo et al., 2016). The gene discussed is PAQR3; the disease is neoplasm.