PLOD3 and lung adenocarcinoma: Accordingly, depletion of PAQR11 in human lung adenocarcinoma cells reduced the secretion of proteins - such as the collagen-modifying enzyme procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3) – that were enriched in Gene Ontology terms, “ECM degradation,” and “proteolysis regulation”.