Additionally, emerging evidence regarding lysosome function, an essential organelle involved in cellular homeostasis suggests that this organelle is susceptible to changes in lipid homeostasis in obesity and LSDs, especially those that accumulate lipids, such as NPC and Gaucher diseases (Dugail 2014; Cermak et al., 2016; Jaishy and Dale Abel 2016; Marques and Saftig 2019). Here, NPC1 is linked to obesity due to melanocortin 4 receptor deficiency.