Moreover, it has been reported, that hepatic extracellular galectin-3 is upregulated in NASH and its inhibition in mice fed with a HFD, reduced hepatic CD36 expression, the accumulation of lipids and hepatic steatosis (Iacobini et al., 2011; Yu et al., 2021). The gene discussed is CD36; the disease is metabolic dysfunction-associated steatohepatitis.