Ninomiya et al. (2021) found that YTHDC1 as well as m6A–writer complex components could be sequestered inside nuclear stress bodies by binding to the m6A-modified lncRNA HSATIII, thereby repressing the m6A-dependent splicing of pre-mRNAs in the nucleoplasm. Recently, Cheng et al. (2021) have proven that m6A-modified mRNA and YTHDC1 can form m6A–YTHDC1 condensates in a phase separation-dependent manner, and this condensate in acute myeloid leukemia cells may protect some mRNA of malignance from degradation. This evidence concerns the gene YTHDC1 and acute myeloid leukemia.