Additionally, in the pulmonary metastasis model, it was found that knockdown of DUXAP8 significantly inhibited the ability of pulmonary metastasis of HCC cells, as evidenced by the reduction in the number of mice with metastatic lung tumors and the decrease in the number of lung tumors in mice treated with NS or sorafenib (Figures 3E,H, Supplementary Figure S3D). The gene discussed is DUXAP8; the disease is hepatocellular carcinoma.