MAPK1 and hepatocellular carcinoma: RNA sequencing analysis revealed that the downregulation of DUXAP8 had a significant effect on the MAPK/ERK pathway, accompanied by the downregulation of MAPK1. Previous studies have reported that MAPK/ERK pathway is closely related to the invasion and migration, proliferation, drug resistance, and glycolysis in HCC (Li et al., 2020a; Li et al., 2020b; He et al., 2020).