AKT1 and cancer: Then we analyzed the changes of the KEGG pathway and found differential expressed genes were mostly related to “cGMP-PKG signaling pathway”, “Cell adhesion molecules”, “Hippo signaling pathway-multiple species”, “Notch signaling pathway”, “MAPK signaling pathway”, “Pathways in cancer”, “PI3K-Akt signaling pathway” and “Transcriptional misregulation in cancer” in 2 cell lines (Figures 5C,D).