Univariate Cox analysis indicated that T follicular helper cells (p = .022), immature B cells (p = .013), mast cells (p = .006), type 17 T helper cells (p = .036), and activated CD8 T cells (p = .036) could serve as independent prognostic protective factors in ccRCC, and MDSC (p < .001) was a remarkable risk indicator for 616 ccRCC patients from the TCGA and CPTAC cohorts (Figure 3C). Here, CD8A is linked to nonpapillary renal cell carcinoma.