STAT3 and nonpapillary renal cell carcinoma: As shown in Figure 8A, TGF-β signaling, oxidative phosphorylation, and fatty acid metabolism were significantly downregulated in ccRCC samples in the m5C scorehigh group compared with the m5C scorelow group, whereas pathways involved in protumorigenesis responses of the TME, such as hypoxia, glycolysis, epithelial-mesenchymal translation, and IL6-JAK/STAT3 signaling, were markedly upregulated in the m5C scorehigh group.