Finally, substantial evidence associate Nrg/Erbb4 signaling to neurodevelopmental disorders (reviewed in(Mei and Nave, 2014)) such as schizophrenia (Norton et al., 2006; Silberberg et al., 2006; Walsh et al., 2008; Mostaid et al., 2017). This evidence concerns the gene ERBB4 and schizophrenia.